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The Virtual Journal of Nanotechnology Environment, Health and Safety
A research paper published in the European Respiratory Journal documents for the first time a clinical case in which a team of medical doctors concluded that exposure to nanoparticles was determined to have resulted in harm to workers.
The medical case study documents in clinical detail the cases of seven women who were hospitalized for pulmonary health problems after workplace exposure to ~30 nm nanoparticles contained in or produced by the spraying of a polyacrylic ester paste. An extensive clinical evaluation was undertaken to determine the cause of the workers’ respiratory symptoms, which included shortness of breath, buildup of fluid in the chest cavity (pleural effusion) and around the heart (pericardial effusion) and itching on the face and arms. The clinical findings included nonspecific pulmonary inflammation, pulmonary fibrosis and foreign-body granulomas in the pleura. Ultimately, two of the women died from respiratory failure and others exhibited persistent lung dysfunction 20 months after first being hospitalized. The women’s clinical symptoms are consistent with the outcomes of animal studies in which nanoparticles have been intentionally introduced into the lungs.
For more about this study, see the entry in the Virtual Journal listings below ("Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and garnuloma") and read the blog postings here and here.
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Nanoparticle Emission Assessment Technique (NEAT) for the Identification and Measurement of Potential Inhalation Exposure to Engineered Nanomaterials - Part A
Methner M, Hodson L, Geraci C
Journal of Occupational and Environmental Hygiene
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Nanoparticle Emission Assessment Technique (NEAT) for the Identification and Measurement of Potential Inhalation Exposure to Engineered Nanomaterials - Part B: Results from 12 Field Studies
Methner M, Hodson L, Dames A, Geraci C
Journal of Occupational and Environmental Hygiene
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Probabilistic material flow modeling for assessing the environmental exposure to compounds: Methodology and an application to engineered nano-TiO2 particles
Gottschalk F, Scholz RW, Nowack B
Environmental Modelling & Software
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Airway Exposure to Silica-Coated TiO2 Nanoparticles Induces Pulmonary Neutrophilia in Mice
Rossi EM, Pylkkanen L, Koivisto AJ, Vippola M, Jensen KA, Miettinen M, Sirola K, Nykasenoja H, Karisola P, Stjernvall T, Vanhal E, Kiilunen M, Pasanen P, Makinen M, Hameri K, Joutsensaari J, Tuomi T, Jokiniemi J, Wolff H, Savolainen K, Alenius H
Toxicological Sciences
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The effect of PEG-coated gold nanoparticles on the anti-proliferative potential of Specific Nutrient Synergy
Harakeh S, Abdel-Massih RM, Gil PR, Sperling RA, Meinhardt A, Niedwiecki A, Rath M, Parak WJ, Baydoun E
Nanotoxicology
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Nanoparticles, human health hazard and regulation
Seaton A, Tran L, Aitken R, Donaldson K
Journal of the Royal Society Interface
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The 5 principles of "Design for Safer Nanotechnology"
Morose G
Journal of Cleaner Production
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A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics
Johnston HJ, Hutchison GR, Christensen FM, Peters S, Hankin S, Aschberger K, Stone V
Nanotoxicology
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Dextrin nanoparticles: Studies on the interaction with murine macrophages and blood clearance
Goncalves C, Torrado E, Martins T, Pereira P, Pedrosa J, Gama M
Colloids and Surfaces B: Biointerfaces
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Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells
Yuan Y, Liu C, Qian J, Wang J, Zhang Y
Biomaterials
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Reported nanosafety practices in research laboratories worldwide
Balas F, Arruebo M, Urrutia J, Santamaria J
Nature Nanotechnology
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The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes
Shvedova AA, Kagan VE
Journal of Internal Medicine
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Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
Oberdorster G
Journal of Internal Medicine
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Cytotoxicity and biological effects of functional nanomaterials delivered to various cell lines
Mahmood M, Casciano DA, Mocan T, Iancu C, Xu Y, Mocan L, Iancu DT, Dervishi E, Li Z, Abdalmuhsen M, Biris A, Ali N, Howard P, Biris AS
Journal of Applied Toxicology
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Endotoxin contamination of engineered nanomaterials
Esch RK, Han L, Foarde KK, Ensor DS
Nanotoxicology
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Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: Short and long-term studies in mice
Gillespie PA, Kang GS, Elder ACP, Gelein R, Chen L, Moreira AL, Koberstein J, Tchou-Wong KM, Gordon T, Chen LC
Nanotoxicology
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Zinc oxide nanoparticles in modern sunscreens: An analysis of potential exposure and hazard
Osmond MJ, McCall MJ
Nanotoxicology
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Expression of inflammation-related cytokines following intratracheal instillation of nickel oxide nanoparticles
Morimoto Y, Ogami A, Todoroki M, Yamamoto M, Horohashi M, Oyabu T, Myojo T, Nishi KI, Kodoya C, Yamasaki S, Nagatomo H, Fujita K, Endoh S, Uchida K, Yamamoto K, Kobayashi N, Nakanishi J, Tanaka I
Nanotoxicology
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Silver nanoparticles up-regulate Connexin43 expression and increase gap junctional intercellular communication in human lung adenocarcinoma cell line A549
Deng F, Olesen P, Foldbjerg R, Dang DA, Guo X, Autrup H
Nanotoxicology
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Study of the influence of the metal complex on the cytotoxic activity of titanocene-functionalized mesoporous materials
Kaluderovic GN, Perez-Quintanilla D, Sierra I, Prashar S, del Hierro I, Zizak Z, Juranic ZD, Fajardo M, Gomez-Ruiz S
Journal of Materials Chemistry
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Interaction of Gold Nanoparticles with Common Human Blood Proteins
Lacerda SHD, Park JJ, Meuse C, Pristinski D, Becker ML, Karim A, Douglas JF
ACS Nano
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In vitro biocompatibility of nanoscale zerovalent iron particles (NZVI) synthesized using tea polyphenols
Nadagouda MN, Castle AB, Murdock RC, Hussain SM, Varma RS
Green Chemistry
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Nanomaterial standards for efficacy and toxicity assessment
Adiseshaiah PP, Hall JB, McNeil SE
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,
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The influence of proteins on the dispersability and cell-biological activity of silver nanoparticles
Kittler S, Greulich C, Gebauer JS, Diendorf J, Treul L, Ruiz L, Gonzales-Calbet JM, Vallet-Regi M, Zellner R, Koller M, Epple M
Journal of Materials Chemistry
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Deposition and biokinetics of inhaled nanoparticles
Geiser M, Kreyling WG
Particle and Fibre Toxicology
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Redefining risk research priorities for nanomaterials
Grieger KD, Baun A, Owen R
Journal of Nanoparticle Research
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SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells
Yang X, Liu J, He H, Zhou L, Gong C, Wang X, Yang L, Yuan J, Huang H, He L, Zhang B, Zhuang Z
Particle and Fibre Toxicology
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Toxicities of nano zinc oxide to five marine organisms: influences of aggregate size and ion solubility
Wong SWY, Leung PTY, Djurisic AB, Leung KMY
Analytical and Bioanalytical Chemistry
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Genotoxic potential of TiO2 on bottlenose dolphin leukocytes
Bernardeschi M, Guidi P, Scarcelli V, Frenzilli G, Nigro M
Analytical and Bioanalytical Chemistry
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Uptake and biological responses to nano-Fe versus soluble FeCl3 in excised mussel gills
Kadar E, Lowe DM, Sole M, Fisher AS, Jha AN, Readman JW, Hutchinson TH
Analytical and Bioanalytical Chemistry
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The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos
Laban G, Nies LF, Turco RF, Bickham JW, Sepulveda MS
Ecotoxicology
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Polyglycol-templated synthesis of poly(N-isopropyl acrylamide) microgels with improved biocompatibility
Chastek TT, Wadajkar A, Nguyen KT, Hudson SD, Chastek TQ
Colloid and Polymer Science
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In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines
Choi JY, Lee SH, Na HB, An K, Hyeon T, Seo TS
Bioprocess and Biosystems Engineering
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Rapid Determination of Nanotoxicity Using Luminous Bacteria
Zheng H, Liu L, Lu Y, Long Y, Wang L, Ho KP, Wong KY
Analytical Sciences
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Potential for Occupational Exposure to Engineered Carbon-Based Nanomaterials in Environmental Laboratory Studies
Johnson DR, Methner MM, Kennedy AJ, Steevens JA
Environmental Health Perspectives
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Ecotoxicity of nanoparticles of CuO and ZnO in natural water
Blinova I, Ivask A, Heinlaas M, Mortimer M, Kahru A
Environmental Pollution
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Evaluating the cytotoxicity of palladium/magnetite nano-catalysts intended for wastewater treatment
Hildebrand H, Kuhnel D, Potthoff A, Mackenzie K, Springer A, Schirmer K
Environmental Pollution
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Effects and uptake of gold nanoparticles deposited at the air-liquid interface of a human epithelial airway model
Brandenberger C, Rothen-Rutishauser B, Muhlfeld C, Schmid O, Ferron GA, Maier KL, Gehr P, Lenz AG
Toxicology and Applied Pharmacology
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Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro
Johnston HJ, Semmler-Behnke M, Brown DM, Kreyling W, Tran L, Stone V
Toxicology and Applied Pharmacology
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Role of oxidative damage in toxicity of particulates
Moller P, Jacobsen NR, Folkmann JK, Danielsen PH, Mikkelsen L, Hemmingsen JG, Vesterdal LK, Forchhammer L, Wallin H, Loft S
Free Radical Research
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Synthesis and Characterization of Stable Monodisperse Silica Nanoparticle Sols for in Vitro Cytotoxicity Testing
Thomassen LCJ, Aerts A, Rabolli V, Lison D, Gonzales L, Kirsch-Volders M, Napierska D, Hoet PH, Kirschhock CEA, Martens JA
Langmuir
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In vitro and in vivo performance of biocompatible negatively-charged salbutamol-loaded nanoparticles
Rytting E, Bur M, Cartier R, Bouyssou T, Wang X, Kruger M, Lehr CM, Kissel T
Journal of Controlled Release
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Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications
Fadeel B, Garcia-Bennett AE
Advanced Drug Delivery Reviews
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Personal protective equipment against nanoparticles
Dolez PI, Bodila N, Lara J, Truchon G
International Journal of Nanotechnology
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A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles
Mahmoudi M, Simchi A, Imani M, Shokgozar MA, Milani AS, Hafeli UO, Stroeve P
Colloids and Surfaces B: Biointerfaces
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(1 ratings)
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Airborne Nanoparticle Exposures while Using Constant-Flow, Constant-Velocity, and Air-Curtain-Isolated Fume Hoods
Tsai SJ, Huang RF, Ellenbecker MJ
Annals of Occupational Hygiene
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Interactions of aluminum nanoparticles with human epidermal keratinocytes
Monteiro-Riviere NA, Ildenburg SJ, Inman AO
Journal of Applied Toxicology
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Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents
Xia XR, Monteiro-Riviere NA, Riviere JE
Toxicology and Applied Pharmacology
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Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes
Zhang LW, Monteiro-Riviere NA
Toxicology In Vitro
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Phototoxicity and cytotoxicity of fullerol in human retinal pigment epithelial cells
Wielgus AR, Zhao B, Chignell CF, Hu DN, Roberts JE
Toxicology and Applied Pharmacology
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Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment
Abrams MT, Koser ML, Seitzer J, Williams SC, FiPietro MA, Wang W, Shaw AW, Mao X, Jadhav V, Davide JP, Burke PA, Sachs AB, Stirdivant SM, Sepp-Lorensino L
Molecular Therapy
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Picosecond and Femtosecond Laser Machining May Cause Health Risks Related to Nanoparticle Emission
Barcikowski S, Walter J, Hahn A, Koch J, Haloui H, Herrmann T, Gatti A
Journal of Laser Micro/NanoEngineering
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Transplacental transport of nanomaterials
Saunders M
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,
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Characterization of nanomaterials for toxicity assessment
Sayes CM, Warheit DB
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,
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Effects of fullerenol C60(OH)24 on the frequency of micronuclei and chromosome aberrations in CHO-K1 cells
Mrdanovic J, Solajic S, Bogdanovic V, Stankov K, Bogdanovic G, Djordjevic A
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
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Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells
Nair S, Sasidharan A, Divya Rani VV, Menon D, Nair S, Manzoor K, Raina S
Journal of Materials Science: Materials in Medicine
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The generation of nanocolloidal wear from stainless steel and titanium alloy and its toxic effects in a monocyte cell culture model
Podleska LE, Weuster M, Buescher R, Hussmann B, Nast-Kolb D, Taeger G
Materialwissenschaft und Werkstofftechnik
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Photoluminescent Diamond Nanoparticles for Cell Labeling: Study of the Uptake Mechanism in Mammalian Cells
Faklaris O, Joshi V, Irinopoulous T, Tauc P, Sennour M, Girard H, Gesset C, Arnault JC, Thore A, Boudou JP, Curmi PA, Treussart F
ACS Nano
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Characterisation of carbon nanotubes in the context of toxicity studies
Berhanu D, Dybowska A, Misra AK, Stanley CJ, Ruenraroengsak P, Boccaccini AR, Tetley TD, Luoma SN, Plant JA, Valsami-Jones E
Environmental Health
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Review of the OSHA Framework for Oversight of Occupational Environments
Choi JY, Ramachandran G
The Journal of Law, Medicine & Ethics
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Commentary: Oversight of Engineered Nanomaterials in the Workplace
Maynard AD
The Journal of Law, Medicine & Ethics
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Uptake and cytotoxicity of poly(d,l-lactide-co-glycolide) nanoparticles in human colon adenocarcinoma cells
Katsikari A, Patronidou C, Kiparissides C, Arsenakis M
Materials Science and Engineering: B
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In vitro effects of SWCNT: Role of treatment duration
Bruinink A, Manser P, Hasler S
Physica Status Solidi B
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Realtime Cytotoxicity Characterization with Cell-Microelectronic Sensing of Water Soluble Carbon Nanotubes
Ren DM, Li M, Dong YY, Cheng Y, Yang XR, Zou YD, Zheng HY, Bai H, Chu XG, Wang JB
Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry
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Expression of cytokine-induced neutrophil chemoattractant in rat lungs by intratracheal instillation of nickel oxide nanoparticles
Nishi K, Morimoto Y, Ogami A, Murakami M, Myojo T, Oyabu T, Kadoya C, Yamamoto M, Todoroki M, Hirohashi M, Yamasaki S, Fujita K, Endo S, Uchida K, Yamamoto K, Nakanishi J, Tanaka I
Inhalation Toxicology
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Exposure to Titanium Dioxide Nanomaterials Provokes Inflammation of an in Vitro Human Immune Construct
Schanen BC, Karakoti AS, Seal S, Drake DR, Warren WL, Self WT
ACS Nano
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| Last updated on February 9, 2010 |
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