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The Virtual Journal of Nanotechnology Environment, Health and Safety
Backgrounder: Multi-walled Carbon Nanotubes and Mesothelioma
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A recent study has demonstrated that multi-walled carbon nanotubes (MWNT) can induce in mice a response similar to that induced by certain asbestos fibers. Exposure to asbestos, a naturally occurring mineral, has been linked in humans to a type of cancer known as mesothelioma, a disease in which malignant cells develop in the mesothelium, a protective lining that covers most of the body’s internal organs. It occurs predominantly in the pleura, which lines the lungs and chest cavity, but can also occur in the peritoneum, the lining of the abdominal cavity, or the pericardium, a sac that surrounds the heart. The disease is almost always caused by exposure to certain forms of asbestos and is a response to particles with a high length-to-width (aspect) ratio, that is, particles that are long and thin.
This ICON Backgrounder reviews the findings of the study, gathers commentaries from the authors and other subject-matter experts, provides resources for additional reading and links to a forum where you can further discuss this work. (read more)
Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
Takagi, A.; Hirose, A.; Nishimura, T.; Fukumori, N.; Ogata, A.; Ohashi, N.; Kitajima, S.; Kanno, J. The Journal of Toxicological Sciences 2008, 33, 105-116.
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Industrially synthesized single-walled carbon nanotubes: compositional data for users, environmental risk assessments, and source apportionment
Plata, D. L.; Gschwend, P. M.; Reddy, C. M.
Nanotechnology
Plata, D. L.; Gschwend, P. M.; Reddy, C. M. Nanotechnology 2008, 185706.
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A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice
Schipper, M. L.; Nakayama-Ratchford, N.; Davis, C. R.; Kam, N. W. S.; Chu, P.; Liu, Z.; Sun, X.; Dai, H.; Gambhir, S. S.
Nature Nanotechnology
Schipper, M. L.; Nakayama-Ratchford, N.; Davis, C. R.; Kam, N. W. S.; Chu, P.; Liu, Z.; Sun, X.; Dai, H.; Gambhir, S. S. Nature Nanotechnology 2008, 3, 216-221.
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Nanotoxicology: Are carbon nanotubes safe?
Zhao, Y.; Xing, G.; Chai, Z.
Nature Nanotechnology
Zhao, Y.; Xing, G.; Chai, Z. Nature Nanotechnology 2008, 3, 191-192.
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Expert opinion on nanotechnology: risks, benefits, and regulation
Besley, J. C.; Kramer, V. L.; Priest, S. H.
Journal of Nanoparticle Research
Besley, J. C.; Kramer, V. L.; Priest, S. H. Journal of Nanoparticle Research 2008, 10, 549-558.
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Occupational Risk Management of Engineered Nanoparticles
Schulte, P.; Geraci, C.; Zumwalde, R.; Hoover, M.; Kuempel, E.
Journal of Occupational and Environmental Hygiene
Schulte, P.; Geraci, C.; Zumwalde, R.; Hoover, M.; Kuempel, E. Journal of Occupational and Environmental Hygiene 2008, 5, 239 - 249.
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Use of Nanoparticles in Swiss Industry: A Targeted Survey
Schmid, K.; Riediker, M.
Environ. Sci. Technol.
Schmid, K.; Riediker, M. Environ. Sci. Technol. 2008, 42, 2253-2260.
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Health and Safety Practices in the Nanomaterials Workplace: Results from an International Survey
Conti, J. A.; Killpack, K.; Gerritzen, G.; Huang, L.; Mircheva, M.; Delmas, M.; Harthorn, B. H.; Appelbaum, R. P.; Holden, P. A.
Environ. Sci. Technol.
Conti, J. A.; Killpack, K.; Gerritzen, G.; Huang, L.; Mircheva, M.; Delmas, M.; Harthorn, B. H.; Appelbaum, R. P.; Holden, P. A. Environ. Sci. Technol. 2008, DOI:10.1021/es702158q
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Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective
Krauze, M. T.; Vandenberg, S. R.; Yamashita, Y.; Saito, R.; Forsayeth, J.; Noble, C.; Park, J.; Bankiewicz, K. S.
Experimental neurology
Krauze, M. T.; Vandenberg, S. R.; Yamashita, Y.; Saito, R.; Forsayeth, J.; Noble, C.; Park, J.; Bankiewicz, K. S. Exp Neurol 2008, 210, 638-44.
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Single walled carbon nanotubes (SWCNT) affect cell physiology and cell architecture
Kaiser, J. P.; Wick, P.; Manser, P.; Spohn, P.; Bruinink, A.
Journal of Materials Science-Materials in Medicine
Kaiser, J. P.; Wick, P.; Manser, P.; Spohn, P.; Bruinink, A. Journal of Materials Science-Materials in Medicine 2008, 19, 1523-1527.
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Technical Challenges Associated with Assessing in vitro Pulmonary Toxicity of Carbon Nanotubes
Snyder R, Zucker R, Jaskot R, Dreher K
The Toxicologist
The Toxicologist 102, Number 1:A1504, 2008
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Nano sphere-mediated deliver of vascular endothelial growth factor gene for therapeutic angiogenesis in mouse ischemic limbs
Kang, S. W.; Lim, H. W.; Seo, S. W.; Jeon, O.; Lee, M.; Kim, B. S.
Biomaterials
Kang, S. W.; Lim, H. W.; Seo, S. W.; Jeon, O.; Lee, M.; Kim, B. S. Biomaterials 2008, 29, 1109-1117.
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Polycarbonate microspheres containing tumor necrosis factor-alpha genes and magnetic powder as potential cancer therapeutics
Hu, B.; Yan, G. P.; Zhuo, R. X.; Wu, Y.; Fan, C. L.
Journal of Applied Polymer Science
Hu, B.; Yan, G. P.; Zhuo, R. X.; Wu, Y.; Fan, C. L. Journal of Applied Polymer Science 2008, 107, 3343-3349.
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Magnetic resonance imaging of contrast-enhanced polyelectrolyte complexes
Huang, M.; Huang, Z. L.; Bilgen, M.; Berkland, C.
Nanomedicine
Huang, M.; Huang, Z. L.; Bilgen, M.; Berkland, C. Nanomedicine 2008, 4, 30-40.
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Research on the structure and performance of bacterial magnetic nanoparticles
Han, L.; Li, S. Y.; Yang, Y.; Zhao, F. M.; Huang, J.; Chang, J.
Journal of Biomaterials Applications
Han, L.; Li, S. Y.; Yang, Y.; Zhao, F. M.; Huang, J.; Chang, J. Journal of Biomaterials Applications 2008, 22, 433-448.
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Acute pulmonary effects of combined exposure to carbon nanotubes and ozone in mice
Han, S. G.; Andrews, R.; Gairola, C. G.; Bhalla, D. K.
Inhalation Toxicology
Han, S. G.; Andrews, R.; Gairola, C. G.; Bhalla, D. K. Inhalation Toxicology 2008, 20, 391-398.
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Bactericidal efficacy of nitric oxide-releasing silica nanoparticles
Hetrick, E. M.; Shin, J. H.; Stasko, N. A.; Johnson, C. B.; Wespe, D. A.; Holmuhamedov, E.; Schoenfisch, M. H.
Acs Nano
Hetrick, E. M.; Shin, J. H.; Stasko, N. A.; Johnson, C. B.; Wespe, D. A.; Holmuhamedov, E.; Schoenfisch, M. H. Acs Nano 2008, 2, 235-246.
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Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube
Takagi, A.; Hirose, A.; Nishimura, T.; Fukumori, N.; Ogata, A.; Ohashi, N.; Kitajima, S.; Kanno, J.
The Journal of Toxicological Sciences
Takagi, A.; Hirose, A.; Nishimura, T.; Fukumori, N.; Ogata, A.; Ohashi, N.; Kitajima, S.; Kanno, J. The Journal of Toxicological Sciences 2008, 33, 105-116.
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Nanomedicine: Application of nanobiotechnology in medical practice
Jain, K. K.
Medical Principles and Practice
Jain, K. K. Medical Principles and Practice 2008, 17, 89-101.
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Surface modified gold nanowires for mammalian cell transfection
Kuo, C. W.; Lai, J. J.; Wei, K. H.; Chen, P.
Nanotechnology
Kuo, C. W.; Lai, J. J.; Wei, K. H.; Chen, P. Nanotechnology 2008, 19, 7.
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Body distribution of inhaled fluorescent magnetic nanoparticles in the mice
Kwon, J. T.; Hwang, S. K.; Jin, H.; Kim, D. S.; Mina-Tehrani, A.; Yoon, H. J.; Chop, M.; Yoon, T. J.; Han, D. Y.; Kang, Y. W.; Yoon, B. I.; Lee, J. K.; Cho, M. H.
Journal of Occupational Health
Kwon, J. T.; Hwang, S. K.; Jin, H.; Kim, D. S.; Mina-Tehrani, A.; Yoon, H. J.; Chop, M.; Yoon, T. J.; Han, D. Y.; Kang, Y. W.; Yoon, B. I.; Lee, J. K.; Cho, M. H. Journal of Occupational Health 2008, 50, 1-6.
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Self-interest, self-restraint and corporate responsibility for nanotechnologies: Emerging dilemmas for modern managers
Lee, R.; Jose, D.
Technology Analysis & Strategic Management
Lee, R.; Jose, D. Technology Analysis & Strategic Management 2008, 20, 113-125.
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[Health effects of nanoparticles and nanomaterials (I) recent oveview of health effects of nanoparticles]
Hirano, S.
Nippon Eiseigaku Zasshi
Hirano, S. Nippon Eiseigaku Zasshi 2008, 63, 36-41.
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Bimodal paramagnetic and fluorescent liposomes for cellular and tumor magnetic resonance imaging
Kamaly, N.; Kalber, T.; Ahmad, A.; Oliver, M. H.; So, P. W.; Herlihy, A. H.; Bell, J. D.; Jorgensen, M. R.; Miller, A. D.
Bioconjugate Chemistry
Kamaly, N.; Kalber, T.; Ahmad, A.; Oliver, M. H.; So, P. W.; Herlihy, A. H.; Bell, J. D.; Jorgensen, M. R.; Miller, A. D. Bioconjugate Chemistry 2008, 19, 118-129.
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| Last updated on May 16, 2008 |
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