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Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply?
Link to Journal Abstract
The continued development and use of engineered nanomaterials (ENM) has given rise to concerns over the potential for human health effects. Although the understanding of cardiovascular ENM toxicity is improving, one of the most complex and acutely demanding ôspecialö circulations is the enhanced maternal system to support fetal development. The Barker hypothesis proposes that fetal development within a hostile gestational environment may predispose/program future sensitivity. Therefore, the objective of this study was 2-fold: (1) to determine whether maternal ENM exposure alters uterine and/or fetal microvascular function and (2) test the Barker hypothesis at the microvascular level. Study Design Pregnant (gestation day 10) Sprague-Dawley rats were exposed to nano-titanium dioxide aerosols (11.3 ▒ 0.039 mg/m3/hr, 5 hr/d, 8.2 ▒ 0.85 days) to evaluate the maternal and fetal microvascular consequences of maternal exposure. Microvascular tissue isolation (gestation day 20) and arteriolar reactivity studies (<150 ým passive diameter) of the uterine premyometrial and fetal tail arteries were conducted. Results ENM exposures led to significant maternal and fetal microvascular dysfunction, which was seen as robustly compromised endothelium-dependent and -independent reactivity to pharmacologic and mechanical stimuli. Isolated maternal uterine arteriolar reactivity was consistent with a metabolically impaired profile and hostile gestational environment that impacted fetal weight. The fetal microvessels that were isolated from exposed dams demonstrated significant impairments to signals of vasodilation specific to mechanistic signaling and shear stress. Conclusion To our knowledge, this is the first report to provide evidence that maternal ENM inhalation is capable of influencing fetal health and that the Barker hypothesis is applicable at the microvascular level.
The objective of this study was 2-fold: (1) to determine whether maternal engineered nanomaterials (ENM) exposure alters uterine and/or fetal microvascular function and (2) test the Barker hypothesis at the microvascular level. Pregnant (gestation day 10) Sprague-Dawley rats were exposed to nano-titanium dioxide aerosols to evaluate the maternal and fetal microvascular consequences of maternal exposure. Microvascular tissue isolation (gestation day 20) and arteriolar reactivity studies of the uterine premyometrial and fetal tail arteries were conducted.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
American Journal of Obstetrics and Gynecology, 209(3): 227.e1-227.e-11 (September 2013)
American Journal of Obstetrics and Gynecology
Stapleton PA, Minarchick VC, Yi J, Engels K, McBride CR, Nurkiewicz TR
227.e1 - 227.e11
Last updated on September 19, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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