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Zinc Oxide Nanoparticles Induce Cell Filamentation in Escherichia coli
Link to Journal Abstract
Zinc oxide nanoparticles (ZnO NPs) induce morphological transformation of Escherichia coli from its native rod-shape of ¡Ö2¨C4 ¦Ìm to filamentous cells of 20¨C40 ¦Ìm in length. The transient response can only be observed at up to 3.5 h proliferation, beyond which the cytotoxic effect is neutralized and the rod-shape is restored. The filamentation is part of the bacterium SOS response to the Trojan horse-type internalization of undissolved ZnO solids. In the absence of ZnO solids, no cell filamentation can be observed from the leached soluble zinc fraction or dissolved zinc salt.
In this study, the authors investigate the ability for zinc oxide nanoparticles (ZnO NPs) to induce morphological transformation of Escherichia coli from its native rod-shape of to filamentous cells.
Peer Reviewed Journal Article
Exposure Or Hazard Target
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Particle & Particle Systems Characterization, 30(4): 375-380 (April 2013)
Particle & Particle Systems Characterization
Gunawan C, Teoh WY, Marquis CP, Amal R
Last updated on June 4, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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