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Cytotoxicity and Antibacterial Activity of Chitosan-organic Rectorite Intercalated Nanofibrous Mats
Link to Journal Abstract
The chitosan (CS)-organic rectorite (OREC) composites are prepared with the method of solution intercalation. Electrospun nanofibrous mats are made from intercalated CS-OREC composites at different mass ratios. The properties and structure of intercalated CS-OREC can be verified by small angle X-ray diffraction (SAXRD) and transmission electron microscopy (TEM) micrographs. Energy dispersive X-ray (EDX) spectroscopy and fourier transform infrared (FT-IR) spectra reveal that OREC presents in the composite nanofibrous mats. The MTT assay indicates that the cytotoxicity of the intercalated CS-OREC nanofibrous mats is low. Besides, the content of OREC in nanofibrous mats has a significant influence on the viability of cells. Antibacterial test confirms that OREC can increase the inhibition rate of the nanofibrous mats against Escherichia coli.
For this study, chitosan (CS)-organic rectorite (OREC) composites have been prepared with the method of solution intercalation and electrospun nanofibrous mats have been made from intercalated CS-OREC composites at different mass ratios. The cytotoxicity of these materials was evaluated by MTT assay.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Current Nanoscience, 9(1): 8-13 (February 2013)
Du J, Li X, Yang C, Li W, Huang W, Huang R, Zhou X, Deng H
Last updated on June 4, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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