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Induced Adaptation of Bacillus sp. to Antimicrobial Nanosilver
Link to Journal Abstract
The natural ability of Bacillus sp. to adapt to nanosilver cytotoxicity upon prolonged exposure is reported for the first time. The combined adaptive effects of nanosilver resistance and enhanced growth are induced under various intensities of nanosilver-stimulated cellular oxidative stress, ranging from only minimal cellular redox imbalance to the lethal levels of cellular ROS stimulation. An important implication of the present work is that such adaptive effects lead to the ultimate domination of nanosilver-resistant Bacillus sp. in the microbiota, to which nanosilver cytotoxicity is continuously applied.
In this work, the authors study the effects of prolonged nanosilver antimicrobial exposure on a model system, in which Escherichia coli is introduced as the target microorganism. Detailed investigations are focused on the post-exposure
potential development of nanosilver-resistant microorganisms as well as on the fate of other members of the microbiota.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Environmental Fate and Transport
Risk Exposure Group
Small, 2013, Early View, DOI: 10.1002/smll.201300761
Gunawan C, Teoh WY, Marquis CP, Amal R
Last updated on May 8, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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