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In vitro studies of calcium phosphate silicate bone cements
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A novel calcium phosphate silicate bone cement (CPSC) was synthesized in a process, in which nanocomposite forms in situ between calcium silicate hydrate (C–S–H) gel and hydroxyapatite (HAP). The cement powder consists of tricalcium silicate (C3S) and calcium phosphate monobasic (CPM). During cement setting, C3S hydrates to produce C–S–H and calcium hydroxide (CH); CPM reacts with the CH to precipitate HAP in situ within C–S–H. This process, largely removing CH from the set cement, enhances its biocompatibility and bioactivity. The testing results of cell culture confirmed that the biocompatibility of CPSC was improved as compared to pure C3S. The results of XRD and SEM characterizations showed that CPSC paste induced formation of HAP layer after immersion in simulated body fluid for 7 days, suggesting that CPSC was bioactive in vitro. CPSC cement, which has good biocompatibility and low/no cytotoxicity, could be a promising candidate as biomedical cement.
This paper presents the synthesis of a novel calcium phosphate silicate bone cement (CPSC) in which nanocomposite forms in situ between calcium silicate hydrate (C–S–H) gel and hydroxyapatite (HAP). The cement powder consists of tricalcium silicate (C3S) and calcium phosphate monobasic (CPM). The biocompatibility of CPSC was tested as compared to pure C3S in cell cultures.
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Journal of Materials Science: Materials in Medicine, 24(2): 355-364 (February 2013)
Journal of Materials Science: Materials in Medicine
Zhou S, Ma J, Shen Y, Haapasalo M, Ruse ND, Yang Q, Troczynski T
Last updated on April 4, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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