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In vivo evaluation of the interaction between titanium dioxide nanoparticle and rat liver DNA
Link to Journal Abstract
Titanium dioxide nanoparticles (TiO2 NPs) are massively produced and widely used in daily life, which may pose potential risk to human health via uncharacterized interaction between DNAs. This research aims to examine the interaction between DNA and three types of TiO2 NPs of different sizes and crystallines. The interaction between TiO2 NPs and liver DNA molecules obtained from Sprague-Dawley rats was systematically evaluated in vivo using atomic force microscopy, transmission electron microscopy, various spectroscopic techniques and gel electrophoresis. We found that TiO2 NPs (diameter <25 nm and <100 nm) in anatase crystalline can covalently interact with liver DNA by either inserting itself in between DNA base pairs or binding to DNA nucleotide via P–O–Ti–O bond. Such interaction may not be NP size-dependent but may be crystalline phase-dependent, because such interaction did not occur in rutile crystal phase, in which the DNA damage was potentially caused by reactive oxygen species.
This research aimed to examine the interaction between DNA and three types of TiO2 nanoparticles (NPs) of different sizes and crystallines. The interaction between TiO2 NPs and liver DNA molecules obtained from Sprague-Dawley rats was systematically evaluated in vivo using atomic force microscopy, transmission electron microscopy, various spectroscopic techniques and gel electrophoresis.
Peer Reviewed Journal Article
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Method Of Study
Risk Exposure Group
Toxicology and Industrial Health, 29(3): 235-244 (April 2013)
Toxicology and Industrial Health
Jin C, Tang Y, Fan XY, Ye XT, Li XL, Tang K, Zhang YF, Li AG, Yang YJ
Last updated on March 29, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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