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Cytotoxicity of release products from magnetic nanocomposites in targeted drug delivery
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The efficacy of chemotherapy can be significantly improved if the therapeutic agent remains localized at the afflicted area and released at controlled rates. Such a targeted drug delivery can be achieved using magnetic nanocomposite (MNC), which incorporates drug and magnetic nanoparticles in biodegradable polymer microspheres. Reported here are results from an in vitro study on drug release rate and cytotoxicity of other release products from MNC. The model system contains an anti-cancer chemotherapy agent 5-flurouracil (5-FU) and (Co0.5Zn0.5)Fe2O4 in poly(lactic-co-glycolic acid) (PLGA) matrix produced by an oil/oil emulsion technique. Cell proliferation data indicate a sustained release of 5-FU for mouse macrophage cell eradication, whereas other microsphere components of magnetic nanoparticles and PLGA have little cytotoxic effects.
Reported in this paper are results from an in vitro study on drug release rate and cytotoxicity of other release products from magnetic nanocomposite (MNC), which incorporates drug and magnetic nanoparticles in biodegradable polymer microspheres.
Peer Reviewed Journal Article
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Journal of Biomaterials Applications, 27(6): 661-667 (February 2013)
Journal of Biomaterials Applications
Wamocha HL, Misak HE, Song Z, Chu HY, Chen YY, Asmatulu R, Yang SY, Ho JC
Last updated on March 6, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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