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Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions
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The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. White blood cells of the immune system—known as leukocytes—possess all of these properties and exert their targeting ability through cellular membrane interactions. Here, we show that nanoporous silicon particles can successfully perform all these actions when they are coated with cellular membranes purified from leukocytes. These hybrid particles, called leukolike vectors, can avoid being cleared by the immune system. Furthermore, they can communicate with endothelial cells through receptor–ligand interactions, and transport and release a payload across an inflamed reconstructed endothelium. Moreover, leukolike vectors retained their functions when injected in vivo, showing enhanced circulation time and improved accumulation in a tumour.
Using a combination of in vitro and in vivo experiments, the authors show in this paper that leukolike vectors (LLVs) are able to avoid opsonization, delay uptake by the mononuclear phagocyte system, preferentially bind inflamed endothelium, and facilitate chemotherapeutics transport across the endothelium while eluding the lysosomal pathway.
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Nature Nanotechnology, 8(1): 61-68 (January 2013)
Parodi A, Quattrocchi N, van de Ven AL, Chiappini C, Evangelopoulos M, Martinez JO, Brown BS, Khaled SZ, Yazdi IK, Enzo MV, Isenhart L, Ferrari M, Tasciotti E
Last updated on February 1, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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