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Emerging Techniques in Proteomics for Probing Nano–Bio Interactions
Link to Journal Abstract
Nanoengineered particles that can facilitate drug formulation and improve specificity of delivery afford exciting opportunities for improved lesion-specific therapy. Understanding and controlling the nano–bio interactions of these materials is central to future developments in this area. Mass-spectrometry-based proteomics techniques, in conjunction with other emerging technologies, are enabling novel insights into the modulation of particle surfaces by biological fluids (formation of the protein corona) and subsequent particle-induced cellular responses. In this Perspective, we summarize important recent developments using proteomics-based techniques to understand nano–bio interactions and discuss the impact of such knowledge on improving particle design.
In this Perspective, the authors summarize important recent developments using proteomics-based techniques to understand nano–bio interactions and discuss the impact of such knowledge on improving particle design.
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ACS Nano, 2012, 6(12): 10438-10448
Lai ZW, Yan Y, Caruso F, Nice EC
Last updated on January 30, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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