ICON Web & News
Search Using OECD Database
Return to Previous Page
Addition or Correction
Real-time impedance analysis of silica nanowire toxicity on epithelial breast cancer cells
Link to Journal Abstract
Silica nanowires have great potential for usage in the development of highly sensitive in vivo biosensors used for biomarker monitoring. However, careful analysis of nanowire toxicity is required prior to placing these sensors within the human body. This paper describes a real-time and quantitative analysis of nanowire cytotoxicity using impedance spectroscopy; improving upon studies that have utilized traditional endpoint assays. Silica nanowires were grown using the vapor liquid solid (VLS) method, mixed with Dulbecco's Modified Eagle Medium (DMEM) and exposed to Hs578T epithelial breast cancer cells at concentrations of 0 ¦Ìg ml−1, 1 ¦Ìg ml−1, 50 ¦Ìg ml−1 and 100 ¦Ìg ml−1. Real-time cellular responses to silica nanowires confirm that while not cytotoxic, silica nanowires at high concentrations (¡Ý50 ¦Ìg ml−1) are toxic to cells, and also suggest that cell death is due to mechanical disturbances of high numbers of nanowires.
This paper describes a real-time and quantitative analysis of nanowire cytotoxicity using impedance spectroscopy; improving upon studies that have utilized traditional endpoint assays.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Analyst, 137(24): 5823-5828 (December 2012)
Alexander FA, Huey EG, Price DT, Bhansali S
Last updated on January 16, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
Why Join Us?
Mission and Strategy
Good Nano Guide
Nano EHS Research Needs
Current Practices Survey