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Title: Cytotoxic aspects of gadolinium oxide nanostructures for up-conversion and NIR bioimaging
Date: 1/2013
  Link to Journal Abstract
Abstract: Bioimaging is an important diagnostic tool in the investigation and visualization of biological phenomena in cells and in medicine. In this context, up-converting Gd2O3:Er3+,Yb3+ nanostructures (nanoparticles, nanorods) have been synthesized by precipitation methods and hydrothermal synthesis. Independent of size and morphology, Gd2O3:Er3+,Yb3+ powders show up-conversion (550 nm, 670 nm) and near-infrared emission (1.5 ìm) upon 980 nm excitation, which makes these structures interesting for application as biomarkers. With regard to their potential application in bioimaging, cytotoxicity is an important aspect and is strongly affected by the physico-chemical properties of the investigated nanostructures. Therefore, the cytotoxic effect of bare and poly(ethylene glycol)-b-poly(acrylic acid) block co-polymer-modified nanostructures on non-phagocytic and phagocytic cells (B-cell hybridoma cells and macrophages) was investigated. The observed cytotoxic behavior in the case of macrophages incubated with bare nanostructures was assigned to the poor chemical durability of gadolinium oxide, but could be overcome by surface modification.
Non-technical Summary: For this study, the cytotoxic effect of bare and poly(ethylene glycol)-b-poly(acrylic acid) block co-polymer-modified Gd2O3:Er3+,Yb3+ nanostructures (nanoparticles, nanorods) on non-phagocytic and phagocytic cells (B-cell hybridoma cells and macrophages) was investigated.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Mammalian
Exposure Pathway Other/Unspecified
Method Of Study In Vitro
Paper Type Hazard
Particle Type Other/Unspecified
Production Method Engineered
Risk Exposure Group General Population
Target Audience Technical Research
Citation: Acta Biomaterialia, 9(1): 4734-4743 (January 2013)
Publication: Acta Biomaterialia
Author: Hemmer E, Yamano T, Kishimoto H, Venkatachalam N, Hyodo H, Soga K
Volume: 9
Number: 1
Pages: 4734-4743
     


Last updated on January 9, 2013
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
Rice University