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Title: Unraveling Stress-Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism
Date: 10/2012
  Link to Journal Abstract
Abstract: Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.
Non-technical Summary: This study used a simple animal model, Caenorhabditis elegans ( C. elegans ) to investigate in vivo the toxic profile of graphene oxide (GO) and functionalized GO modified with PEGylated poly-L-lysine (PLL-PEG) (GO/PP) under both normal and stress conditions. With this simple model, the potential in vivo toxicity of nanosheets under stress was studied.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Other/Unspecified
Exposure Pathway Other/Unspecified
Method Of Study Other
Paper Type Hazard
Particle Type Carbon
Production Method Engineered
Risk Exposure Group Other/Unspecified
Target Audience Technical Research
Citation: Advanced Materials, 24(39): 5391-5397 (October 2012)
Publication: Advanced Materials
Author: Zhang W, Wang C, Li Z, Lu Z, Li Y, Yin JJ, Zhou YT, Gao X, Fang Y, Nie G, Zhao Y
Volume: 24
Number: 39
Pages: 5391-5397
     


Last updated on November 27, 2012
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
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