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Unraveling Stress-Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism
Link to Journal Abstract
Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.
This study used a simple animal model, Caenorhabditis elegans ( C. elegans ) to investigate in vivo the toxic profile of graphene oxide (GO) and functionalized GO modified with PEGylated poly-L-lysine (PLL-PEG) (GO/PP) under both normal and stress conditions. With this simple model, the potential in vivo toxicity of nanosheets under stress was studied.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Advanced Materials, 24(39): 5391-5397 (October 2012)
Zhang W, Wang C, Li Z, Lu Z, Li Y, Yin JJ, Zhou YT, Gao X, Fang Y, Nie G, Zhao Y
Last updated on November 27, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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