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Title:

Biodistribution study of carbogenic dots in cells and in vivo for optical imaging

Date:

10/2012

Link to Journal Abstract

Abstract:

Blue fluorescent carbon dots (C-dots) were synthesized and evaluated for their cytotoxicity and also for their optical imaging performance. The results showed that the C-dots could enter into the Hela cells in 15 min incubation and the uptake increased rapidly from 15 min to 2 h. In cytotoxicity study, C-dots were biocompatible and nontoxic to three human cells including two cancer cells (Hela and SMCC-7721) and one normal cell (HEK 293) in concentrations up to 500 ?g/mL. Since the endocytic interference factors, including NaN3, M?CD, sucrose, and low temperature, could not play an inhibitory effect on C-dots entering into cells, the direct nonendocytic pathway for C-dots was speculated. The C-dots showed encouraging cell-imaging applications in vitro and in vivo. They entered into cells without any further functionalization, and the fluorescence property of these particles can be used for fluorescence-based cell-imaging applications.

Non-technical Summary:

For this study, blue fluorescent carbon dots (C-dots) were synthesized and evaluated for their cytotoxicity and also for their optical imaging performance. The cytotoxicity study for the C-dots were determined for three human cells including two cancer cells (Hela and SMCC-7721) and one normal cell (HEK 293).

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Peer Reviewed Journal Article

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