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Title: Toxicity evaluation of CdTe quantum dots with different size on Escherichia coli
Date: 10/2012
  Link to Journal Abstract
Abstract: Quantum dots (QDs) have a great potential for applications in nanomedicine. However, a few studies showed that they also exhibited toxicity. We used Escherichia coli (E. coli) as the model to study the effect of CdTe QDs on the cell growth by microcalorimetric technique, optical density (OD600) and attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra. Three size aqueous-compatible CdTe QDs with maximum emission of 543 nm (green-emitting QDs, GQDs), 579 nm (yellow-emitting QDs, YQDs) and 647 nm (red-emitting QDs, RQDs) were tested. The growth rate constants (k) and half-inhibiting concentration (IC50) were calculated from the microcalorimetric data. The results indicated that CdTe QDs exhibited a dose-dependent inhibitory effect on cell growth. The order of toxicity is GQDs > YQDs > RQDs. The smaller the particle size of QDs is, the more toxicity it is. ATR-FTIR spectra indicated that the outer membrane of the cell was changed or damaged by the QDs, which may induce QDs and harmful by-products to enter into the cells. These could be one of the reasons that CdTe QDs have cytotoxic effects on E. coli.
Non-technical Summary: In this study, the authors used Escherichia coli (E. coli) as the model to study the effect of CdTe quantum dots (QDs) on the cell growth by microcalorimetric technique, optical density (OD600) and attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Other/Unspecified
Exposure Pathway Other/Unspecified
Method Of Study Other
Paper Type Hazard
Particle Type Semiconductor
Production Method Engineered
Risk Exposure Group Ecosystem
Target Audience Technical Research
Citation: Toxicology in Vitro, 26(7): 1233-1239 (October 2012)
Publication: Toxicology in Vitro
Author: Fang TT, Li X, Wang QS, Zhang ZJ, Liu P, Zhang CC
Volume: 26
Number: 7
Pages: 1233-1239
     


Last updated on November 7, 2012
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
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