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Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation
Link to Journal Abstract
The synthesis of 18F-labelled positron emitting NPs by direct irradiation of 18O-enriched aluminum oxide NPs with 16 MeV protons is reported. Biodistribution studies of the labelled particles after intravenous administration were performed in male rats using positron emission tomography. The simple and general activation strategy can be applied to any in situ prepared core metal oxide particle for direct use or subsequent bio-compatible coating or encapsulation followed by functionalization.
This paper reports the synthesis of 18F-labelled positron emitting nanoparticles (NPs) by direct irradiation of 18O-enriched aluminum oxide NPs with 16 MeV protons is reported. Biodistribution studies of the labelled particles after intravenous administration were performed in male rats using positron emission tomography.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
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Analyst, 137(21): 4902-4906 (November 2012)
Perez-Campana C, Gomez-Vallejo V, Martin A, San Sebastian E, Moya SE, Reese T, Ziolo RF, Llop J
Last updated on February 1, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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