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Cytotoxicity and cell imaging potentials of submicron color-tunable yttria particles
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Increased demand of environment protection encouraged scientists to design products and processes that minimize the use and generation of hazardous substances. This work presents comprehensive result of large-scale fabrication and investigation of red-to-green tunable submicron spherical yttria particles codoped with low concentrations of Eu+3 and Tb+3. The color emission of synthesized particles can be precisely tuned from red to green by simple variation of Tb/Eu ratio and excitation wavelength. The Tb/Eu-codoped Y2O3 particles did not adversely affect the viability of L-929 fibroblastic cells at concentrations less than 62.5 ppm. Through internalization and wide distribution inside the cells, Tb/Eu codoped Y2O3 particles with intense bright green or red fluorescence rendered cell imaging to be possible. The high brightness, excellent stability, low-toxicity, and imaging capability along with fine color-tunability of synthesized particles enable to find promising application in various areas.
This work presents comprehensive result of large-scale fabrication and investigation of red-to-green tunable submicron spherical yttria particles codoped with low concentrations of Eu+3 and Tb+3. The viability of the Tb/Eu-codoped Y2O3 particles onL-929 fibroblastic cells was investigated.
Peer Reviewed Journal Article
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Journal of Biomedical Materials Research Part A, 100A(9): 2287-2294 (Sept 2012)
Journal of Biomedical Materials Research Part A
Atabaev TS, Lee JH, Han DW, Hwang YH, Kim HK
Last updated on September 13, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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