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Title:

Cytotoxicity and cell imaging potentials of submicron color-tunable yttria particles

Date:

9/2012

Link to Journal Abstract

Abstract:

Increased demand of environment protection encouraged scientists to design products and processes that minimize the use and generation of hazardous substances. This work presents comprehensive result of large-scale fabrication and investigation of red-to-green tunable submicron spherical yttria particles codoped with low concentrations of Eu+3 and Tb+3. The color emission of synthesized particles can be precisely tuned from red to green by simple variation of Tb/Eu ratio and excitation wavelength. The Tb/Eu-codoped Y2O3 particles did not adversely affect the viability of L-929 fibroblastic cells at concentrations less than 62.5 ppm. Through internalization and wide distribution inside the cells, Tb/Eu codoped Y2O3 particles with intense bright green or red fluorescence rendered cell imaging to be possible. The high brightness, excellent stability, low-toxicity, and imaging capability along with fine color-tunability of synthesized particles enable to find promising application in various areas.

Non-technical Summary:

This work presents comprehensive result of large-scale fabrication and investigation of red-to-green tunable submicron spherical yttria particles codoped with low concentrations of Eu+3 and Tb+3. The viability of the Tb/Eu-codoped Y2O3 particles onL-929 fibroblastic cells was investigated.

Content Emphasis

Peer Reviewed Journal Article

Exposure Or Hazard Target

Exposure Pathway

Method Of Study

Paper Type

Particle Type