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Title: Cognitive impairment in rats induced by nano-CuO and its possible mechanisms
Date: 9/2012
  Link to Journal Abstract
Abstract: Several studies have reported the adverse effects of nano-CuO on hippocampal CA1 neuron, whereas little has been known about nano-CuO neurotoxicity in vivo. In the present study, we investigated the effects of nano-CuO on spatial cognition and electrophysiological alterations in rats. In addition, histological and biochemical changes in rat's hippocampus were measured as well. Morris water maze (MWM) test showed that learning and memory abilities in nano-CuO-treated group were weakened significantly. The long-term potentiation (LTP) test exhibited that field excitatory postsynaptic potentials (fEPSPs) slopes were significantly lower in nano-CuO-treated group compared to that in control group. Furthermore, the levels of ROS and malonaldehyde (MDA) in hippocampal homogenate of nano-CuO-treated group were considerably enhanced while the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were statistically reduced. Moreover, the enhanced 4-hydroxynonenal (HNE) and caspase-3 implied the progression of apoptosis in the hippocampus. The results suggested that the neuronal damage, induced by impairing oxidation–antioxidation homeostasis, led to the impairment of hippocampal LTP, which was associated with the poor performance of animals in behavior tests.
Non-technical Summary: In this study, the authors investigated the effects of nano-CuO on spatial cognition and electrophysiological alterations in rats. In addition, histological and biochemical changes in rat's hippocampus were measured as well.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Mammalian
Exposure Pathway Other/Unspecified
Method Of Study In Vivo
Paper Type Hazard
Particle Type Oxide
Production Method Engineered
Risk Exposure Group General Population
Target Audience Technical Research
Citation: Toxicology Letters, 213(2): 220-227 (September 2012)
Publication: Toxicology Letters
Author: An L, Liu S, Yang Z, Zhang T
Volume: 213
Number: 2
Pages: 220-227
     


Last updated on September 11, 2012
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
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