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Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory
Link to Journal Abstract
The Nanotechnology Characterization Laboratory's (NCL) unique set-up has allowed our lab to handle and test a variety of nanoparticle platforms intended for the delivery of cancer therapeutics and/or imaging contrast agents. Over the last six years, the NCL has characterized more than 250 different nanomaterials from more than 75 different investigators. These submitted nanomaterials stem from a range of backgrounds and experiences, including government, academia and industry. This has given the NCL a unique and valuable opportunity to observe trends in nanoparticle safety and biocompatibility, as well as note some of the common mistakes and oversights of nanoformulation. While not exhaustive, this article aims to share some of the most common pitfalls observed by the NCL as they relate to nanoparticle synthesis, purification, characterization and analysis.
This perspective article, while not exhaustive, aims to share some of the most common pitfalls observed by the Nanotechnology Characterization Laboratory (NCL) as they relate to nanoparticle synthesis, purification, characterization and analysis.
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Integrative Biology, 2013, 5(1): 66-73
Crist RM, Grossman JH, Patri AK, Stern ST, Dobrovolskaia MA, Adiseshaiah PP, Clogston JD, McNeil SE
Last updated on February 1, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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