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Permission to Enter Cell by Shape: Nanodisk vs Nanosphere
Link to Journal Abstract
Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.
This study investigates polystyrene nanospheres and nanodisks with the same diameter and identical surface chemistry for their
interactions with human cells to determine if disk-shaped nanoparticles may bind to, but not be internalized by cells.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
ACS Applied Materials & Interfaces, 2012, 4(8): 4099-4105
ACS Applied Materials & Interfaces
Zhang Y, Tekobo S, Tu Y, Zhou Q, Jin X, Dergunov SA, Pinkhassik E, Yan B
Last updated on February 1, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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