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Title: Permission to Enter Cell by Shape: Nanodisk vs Nanosphere
Date: 8/2012
  Link to Journal Abstract
Abstract: Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.
Non-technical Summary: This study investigates polystyrene nanospheres and nanodisks with the same diameter and identical surface chemistry for their
interactions with human cells to determine if disk-shaped nanoparticles may bind to, but not be internalized by cells.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Mammalian
Exposure Pathway Other/Unspecified
Method Of Study In Vitro
Paper Type Exposure
Particle Type Organic/Polymers
Production Method Engineered
Risk Exposure Group General Population
Target Audience Technical Research
Citation: ACS Applied Materials & Interfaces, 2012, 4(8): 4099-4105
Publication: ACS Applied Materials & Interfaces
Author: Zhang Y, Tekobo S, Tu Y, Zhou Q, Jin X, Dergunov SA, Pinkhassik E, Yan B
Volume: 4
Number: 8
Pages: 4099-4105
     


Last updated on February 1, 2013
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
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