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Title: Nanowire Biocompatibility in the Brain - Looking for a Needle in a 3D Stack
Date: 10/2009
  Link to Journal Abstract
Abstract: We investigated the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry. The nanowires could be visualized in the scar by confocal microscopy (through the scattered laser light). For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain.
Non-technical Summary: In this study, the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry was investigated.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Mammalian
Exposure Pathway Other/Unspecified
Method Of Study In Vivo
Paper Type Hazard
Particle Type Other/Unspecified
Production Method Engineered
Risk Exposure Group General Population
Target Audience Technical Research
Citation: Nano Lett., 2009, Article ASAP, DOI: 10.1021/nl902413x
Publication: Nano Letters
Author: Linsmeier CE, Prinz CN, Pettersson LME, Caroff P, Samuelson L, Schouenborg J, Montelius L, Danielsen N
Volume: Article ASAP
Pages: (7 pp)
     


Last updated on October 22, 2009
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
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