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Title:

Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

Date:

2/2005

Link to Journal Abstract

Abstract:

The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-beta-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals. ADDL concentrations for the subjects diagnosed with AD were consistently higher than the levels in the CSF taken from nondemented age-matched controls. Studies of ADDLs or for any other potential pathogenic AD markers in CSF have not been possible because of their low concentration in CSF (<1 pM). This study is a step toward a diagnostic tool, based on soluble pathogenic markers for the debilitating disease.

Non-technical Summary:

This paper investigates the use of gold NPs as part of a bio-barcode assay to detect a biomarker for Alzheimer's disease in cerebral spinal fluid.

Content Emphasis

Peer Reviewed Journal Article

Target Audience

Technical Research

Citation:

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2273-6. Epub 2005 Feb 4

Publication:

Proceeds of the National Academy of Sciences of the United States of America

Author:

Georganopoulou DG, Chang L, Nam JM, Thaxton CS, Mufson EJ, Klein WL, Mirkin CA