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Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration
Link to Journal Abstract
To achieve deep tumor penetration of large-sized nanoparticles (NPs), we have developed a reversible swelling®Cshrinking nanogel in response to pH variation for a sequential intra-intercellular NP delivery. The nanogel had a crosslinked polyelectrolyte core, consisting of N-lysinal-N°š-succinyl chitosan and poly(N-isopropylacrylamide), and a crosslinked bovine serum albumin shell, which was able to swell in an acidic environment and shrink back under neutral conditions. The swelling resulted in a rapid release of the encapsulated chemotherapeutics in the cancer cells for efficient cytotoxicity. After being liberated from the dead cells, the contractive nanogel could infect neighboring cancer cells closer to the center of the tumor tissue.
To achieve deep tumor penetration of large-sized nanoparticles (NPs), the authors have developed a reversible swelling®Cshrinking nanogel in response to pH variation for a sequential intra-intercellular NP delivery.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Angewandte Chemie, International Edition, 53(24): 6253-6258 (June 2014)
Angewandte Chemie, International Edition
Ju C, Mo R, Xue J, Zhang L, Zhao Z, Xue L, Ping Q, Zhang C
Last updated on July 8, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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