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The acute cytotoxicity of bismuth ferrite nanoparticles on PC12 cells
Link to Journal Abstract
Due to its unique properties, bismuth ferrite (BiFeO3, BFO) has gained a great deal of interest. The prevalence of BFO increases the likelihood of exposures either to environment or to humans. Unfortunately, the understanding of BFO biological effects is very limited. In this study, a battery of standard tests, such as morphology observation, MTT, and LDH assay, and flow cytometry analysis, was employed to elucidate in vitro cytotoxicity of BFO nanoparticles (NPs) in the size range of 30–90 nm using PC12 cells as a model. The results show that BFO-NPs could tightly attach to the cell membrane in the culture medium, which significantly affect the cell adhesion and inhibit their proliferation. Moreover, cytotoxicity of BFO-NPs is greatly mitigated when the exposure time was extended to 48 h. These findings suggest that BFO-NP possess the nature of acute cytotoxicity since the cells can recover to a certain extent over with incubation time. For the first time, our study reveals some essential properties of BFO-NP toxicity, which may advance BFO applications and its toxicological study.
In this study, a battery of standard tests, such as morphology observation, MTT, and LDH assay, and flow cytometry analysis, was employed to elucidate in vitro cytotoxicity of bismuth ferrite (BiFeO3, BFO) nanoparticles (NPs) in the size range of 30–90 nm using PC12 cells as a model.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Journal of Nanoparticle Research, 2014, 16(5): 2408
Journal of Nanoparticle Research
Song Q, Liu Y, Jiang Z, Tang M, Li N, Wei F, Cheng G
Last updated on June 17, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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