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Impact of agglomeration on the bioaccumulation of sub-100 nm sized TiO2
Link to Journal Abstract
To improve our understanding on the impact of extrinsic properties of NPs on their bioaccumulation and toxicity, we have investigated the bioaccumulation of sub 100 nm sized P25 TiO2 nanoparticles (NPs) by Daphnia magna (D. magna) in toxicity testing media. Based on our quantitative ICP-MS measurements as well as spectromicroscopic observations, we found that the bioaccumulation by D. magna were strongly influenced by the extrinsic properties of NPs as well as the biological uptake characteristics of D. magna. New sets of effective dosimetry parameters well correlated with the amount of NPs bioaccumulated within D. magna were also proposed. Based on these findings, we suggested that the extrinsic physicochemical properties of NPs (e.g., interfacial and colloidal properties of NPs) and biological characteristics for NPs (e.g., uptake cutoff sizes of testing organisms) should be considered and included when developing alternative dosimetry of NPs.
To improve our understanding on the impact of extrinsic properties of nanoparticles (NPs) on their bioaccumulation and toxicity, the authors have investigated the bioaccumulation of sub 100 nm sized P25 TiO2 nanoparticles by Daphnia magna (D. magna) in toxicity testing media.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Environmental Fate and Transport
Risk Exposure Group
Colloids and Surfaces B: Biointerfaces, 116: 277-283 (April 2014)
Colloids and Surfaces B: Biointerfaces
Kwon D, Jeon SK, Yoon TH
Last updated on June 13, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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