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Interaction between carbon nanotubes and human cell
Link to Journal Abstract
Carbon nanotubes (CNTs) have been attracting increasing attention for the possibilities of their widespread applications and many studies have been conducted for their development. On the other hand, the research on the influence of CNTs on human organisms is still scarce and some show concerns about genotoxicity or cytotoxicity. Therefore, in this research, we are proposing a new way of biocompatibility evaluation for CNTs by examining the relation between biocompatibility and structure of CNTs. In our cytotoxicity tests, neither chromosome abnormality nor cell cycle dysregulation occurred, evaluated by fluorescence activated cell sorting (FACS) analysis. However, significances were assessed for cell proliferation and viability for semiconducting CNTs by the paired t-test. It is also clear that CNTs showed adherence to cell, since efficiency of cell ablation by trypsin decreased dramatically in CNTs dishes; this phenomenon was observed especially in semiconducting CNTs. Since semiconducting CNTs do not include armchair CNTs while metallic CNTs do, it indicates that armchair CNTs have high possibility of affection toward biocompatibility. It is expected that armchair CNTs change the behavior of cells such as proliferation and viability.
In this study, the authors are proposing a new way of biocompatibility evaluation for carbon nanotubes (CNTs) by examining the relation between biocompatibility and structure of CNTs.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Precision Engineering, 38(1): 116-120 (January 2014)
Tsuchiya K, Limori S, Kajiwara K, Kimura M
Last updated on January 29, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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