ICON Web & News
Search Using OECD Database
Return to Previous Page
Addition or Correction
Impact of Silver Nanoparticles and Silver Ions on Innate Immune Cells
Link to Journal Abstract
Silver is commonly used as an antibacterial agent, e.g., in various medical applications, and the availability of silver nanoparticles (AgNP) has fueled this development. Their antibacterial properties are well defined, whereas there are concerns regarding unknown and potentially harmful effects of AgNPs on immune cells and an ongoing immune reaction. Aim of the present study is a comparison of the effects of AgNPs and ionic silver (Ag+) on cells of the innate immune system, in particular on neutrophil granulocytes and macrophages. The AgNPs were synthesized within hydroxylated polyester dendrimer templates via an in situ approach, generating five kinds of AgNPs with mean diameters from 2.0 to 34.7 nm.4 No impact is observed on phagocytosis and oxidative burst, as well as activation of the promoter for the pro-inflammatory cytokine TNF-á. In contrast, both AgNPs and Ag+, but not the dendrimer templates, trigger the release of neutrophil extracellular traps and inhibit the formation of nitric monoxide. On the molecular level, AgNPs and Ag+ cause elevated intracellular levels of reactive oxygen species and the second messenger Zn2+. Moreover, protein phosphatases are inhibited by an oxidative mechanism. Taken together, there are several effects of AgNPs on neutrophil granulocytes and macrophages in vitro, but these are not specific for AgNP, instead they are also observed with Ag+, and Ag+ released from AgNPs seems to be the component responsible for most of the particles' immunomodulatory activity.
The aim of this study was a comparison of the effects of silver nanoparticles (AgNP) and ionic silver (Ag+) on cells of the innate immune system, in particular on neutrophil granulocytes and macrophages.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Journal of Biomedical Nanotechnology, 10(6): 1146-1156 (June 2014)
Journal of Biomedical Nanotechnology
Haase H, Fahmi A, Mahltig B
Last updated on January 27, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
Why Join Us?
Mission and Strategy
Good Nano Guide
Nano EHS Research Needs
Current Practices Survey