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A low-maintenance, primary cell culture model for the assessment of carbon nanotube toxicity
Link to Journal Abstract
Carbon nanotubes (CNTs) have gained substantial interest as a material for biomedical devices with reliable properties suitable for electrically conducting biomedical devices. While CNTs combine ideal properties for a number of tissue-interfacing applications, their biocompatibility and safety have been the source of considerable conjecture. This study outlines a method for evaluating biocompatibility, using a low-cost, short-term assessment model of CNT with primary cells, which are more representative of an in vivo situation than cell lines. It was demonstrated that carboxylate-modified, multi-walled CNTs exhibit cytotoxic behavior in as little as 6 hr of exposure to primary fibroblasts. The resultant cell death was concentration dependent, demonstrating the efficacy of acute assessment of cytocompatibility. Although cell viability remained relatively high (being above 85% for all CNT concentrations up to 500 ėg/ml), these results reflect similar relationships found for longer term exposures. This method has reliable potential for high-throughput assessment and quality control of CNTs in biomedical applications using a primary cell model.
This study outlines a method for evaluating biocompatibility, using a low-cost, short-term assessment model of carbon nanotubes (CNTs) with primary cells, which are more representative of an in vivo situation than cell lines. This method has reliable potential for high-throughput assessment and quality control of CNTs in biomedical applications using a primary cell model.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Toxicological & Environmental Chemistry, 2013, 95(7): 1129-1144
Toxicological & Environmental Chemistry
Gilmour AD, Green RA, Thomson CE
Last updated on January 22, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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