ICON Web & News
Search Using OECD Database
Return to Previous Page
Addition or Correction
Determination of quantum dots in single cells by inductively coupled plasma mass spectrometry
Link to Journal Abstract
In order to assess cytotoxicity of quantum dots (QDs), new reliable analytical techniques that can provide comparative information at a single-cell level are required. In this study, a single cell ICP–MS (SC-ICP–MS) method was established to determine intracellular QDs in single cells after exposure. Uptake kinetics of QDs into cells was studied using the established method. The results were compared and validated by flow cytometry and cell digestion methods. In contrast to other methods, SC-ICP–MS can directly detect QDs and their degradation products via elements, and thus is a promising complement to available methods for single cell analysis and is expected to be a critical tool in the future.
In this study, a single cell ICP–MS (SC-ICP–MS) method was established to determine intracellular quantum dots (QDs) in single cells after exposure. Uptake kinetics of QDs into cells was studied using the established method. The results were compared and validated by flow cytometry and cell digestion methods.
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Talanta, 116: 782-787 (November 2013)
Zheng LN, Wang M, Wang B, Chen HQ, Ouyang H, Zhao YL, Chai ZF, Feng WY
Last updated on January 14, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
Why Join Us?
Mission and Strategy
Good Nano Guide
Nano EHS Research Needs
Current Practices Survey