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Cytotoxicity of Ultra-pure TiO2 and ZnO Nanoparticles Generated by Laser Ablation
Link to Journal Abstract
This paper aims to address the cellular toxicity of ultra-pure titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) frequently employed in sunscreens as inorganic physical sun blockers to provide protection against adverse effects of ultraviolet (UV) radiation including UVB (290-320 nm) and UVA (320-400 nm). In consideration that the production and the use of inorganic NPs have aroused many concerns and controversies regarding their safety and toxicity and that microsized TiO2 and ZnO have been increasingly replaced by TiO2 and ZnO NPs (< 100 nm), it is very important to directly investigate a main problem related to the intrinsic/inherent toxicity of these NPs and/or their incompatibility with biological objects. In the present study, we took advantage of the laser-assisted method called laser ablation for generation of TiO2 and ZnO NPs. NPs were prepared through a physical process of irradiating solid targets in liquid phase, enabling verification of the toxicity of ultra-pure NPs with nascent surfaces free from any contamination. Our results show that TiO2 NPs are essentially non-poisonous and ZnO NPs are more toxic than TiO2 NPs based on the cell viability assays.
This paper aims to address the cellular toxicity of ultra-pure titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) frequently employed in sunscreens as inorganic physical sun blockers. NPs were prepared through a physical process of irradiating solid targets in liquid phase, enabling verification of the toxicity of ultra-pure NPs with nascent surfaces free from any contamination.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Bulletin of the Korean Chemical Society, 2013, 34(11): 3301-3306
Bulletin of the Korean Chemical Society
Jeong M, Park JM, Lee EJ, Cho YS, Lee C, Kim JM, Hah SS
Last updated on January 9, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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