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Imaging cellular uptake and intracellular distribution of TiO2 nanoparticles
Link to Journal Abstract
Understanding the internalization of nanoparticles in cells is of great interest for diagnostic and therapeutic applications. We investigated the cellular uptake and distribution of TiO2 nanoparticles by high lateral resolution transmission electron microscopy (TEM) and transmission X-ray microscopy. TEM results showed that TiO2 nanoparticle internalization mostly occurred via endocytosis and the nanoparticles were distributed in the cytoplasm. 3D reconstructed tomography also confirmed that TiO2 nanoparticle aggregates were mainly distributed over the cell membrane surface.
For this paper, the authors investigated the cellular uptake and distribution of TiO2 nanoparticles by high lateral resolution transmission electron microscopy (TEM) and transmission X-ray microscopy.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Analytical Methods, 5(23): 6611-6616 (December 2013)
Zhang J, Cai X, Zhang Y, Li X, li W, Tian Y, Li A, Yu X, Fan C, Huang Q
Last updated on January 7, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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