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Cytotoxic Effects of Polystyrene–Titanium–Arsenate Composite in Cultured H9c2 Cardiomyoblasts
Link to Journal Abstract
In the present report, we explored the toxicological behaviour of engineered polystyrene–titanium–arsenate (PS–Ti–As) composite using cultured H9c2 cardiomyoblasts in vitro. From in vitro cytotoxicity studies, it appears that the composite can be toxic to the cardiac cells and the value of IC50 investigated to be the highest concentration of 500 ìg mL−1, during 16–24 h of incubation period. The cell morphological studies based on dual staining with acridine orange and ethidium bromide indicates that apoptosis is the dominating pathway of cell death. Furthermore, an enhanced DNA fragmentation, increased reactive oxygen species production and caspase release demonstrates the potential risks associated with the exposure of PS–Ti–As composite to the cardiac cells.
For this study, the authors explored the toxicological behaviour of engineered polystyrene–titanium–arsenate (PS–Ti–As) composite using cultured H9c2 cardiomyoblasts in vitro.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Bulletin of Environmental Contamination and Toxicology, 91(6): 689-696 (December 2013)
Bulletin of Environmental Contamination and Toxicology
Mohammad F, Arfin T
Last updated on January 3, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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