ICON Web & News
Search Using OECD Database
Return to Previous Page
Addition or Correction
Surface Coating Rescues Proteins from Magnetite Nanoparticle Induced Damage
Link to Journal Abstract
The presence of magnetic nanoparticles (NPs) in physiological systems induces toxicity through its effects on mitochondrial function and reactive oxygen species (ROS) imbalance. Magnetic NP induced cytotoxicity has been elaborately evaluated for impending threats, however, a detailed investigation is lacking. It is shown that the interaction of Fe3O4 NPs with cytochrome c can lead to different events based on the NPs to protein ratio, the solution conditions, and the type of surface protection. At low NPs concentration, rapid binding and subsequent electron transfer are the preferred events while at higher concentration slow oxidative modification of the protein is initiated. The slow event of protein modification yields conformational disorientation, loss of stability, and formation of amyloid-like structures with cytochrome c. The possibility that the NP induced oxidative stress and age can work in concert to compromise different aspects of cellular quality control processes is discussed. Suitable surface modifications of the NPs inhibit their direct binding to the protein molecules and minimize NP induced toxicity.
For this study, the authors show that the interaction of Fe3O4 nanoparticles (NPs) with cytochrome c can lead to different events based on the NPs to protein ratio, the solution conditions, and the type of surface protection. The possibility that the NP induced oxidative stress and age can work in concert to compromise different aspects of cellular quality control processes is discussed.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Particle & Particle Systems Characterization, 30(8): 683-694 (August 2013)
Particle & Particle Systems Characterization
Joshi N, Mukhopadhyay A, Basak S, De G, Chattopadhyay K
Last updated on January 3, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
Why Join Us?
Mission and Strategy
Good Nano Guide
Nano EHS Research Needs
Current Practices Survey