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Physico-chemical, mechanical and cytotoxicity characterizations of Laponite®/alginate nanocomposite
Link to Journal Abstract
Combining clay minerals containing silica with polymers can improve the performance of polymers in biomedical applications by the synergistic combination of physico-chemical and biological properties of both phases. In this study, Laponite® — a synthetic biocompatible and biodegradable silicate clay mineral, was combined with alginate to improve alginate mechanical and biological characteristics. The physico-chemical properties (porosity, degradation, swelling, crystalline structure, compressive strength, and injectability) and biological responses (cytotoxicity and cell morphology) of the Laponite/alginate nanocomposites were investigated in the study. The results showed that the incorporation of Laponite into alginate significantly enhanced alginate compression strength without hindering its injectability when the percentage of clay mineral was below 50%. The prepared clay polymer nanocomposites (CPN) were not toxic and the viability of cells cultured in its extract was indeed higher than alginate alone. However, these prepared CPN poorly supported cell adhesion, probably due to the high degradation rate of the materials.
In this study, Laponite® - a synthetic biocompatible and biodegradable silicate clay mineral, was combined with alginate to improve alginate mechanical and biological characteristics. The physico-chemical properties (porosity, degradation, swelling, crystalline structure, compressive strength, and injectability) and biological responses (cytotoxicity and cell morphology) of the Laponite/alginate nanocomposites were investigated in the study.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Applied Clay Science, 85: 64-73 (November 2013)
Applied Clay Science
Ghadiri M, Chrzanowski W, Lee WH, Fathi A, Dehghani F, Rohanizadeh R
Last updated on January 2, 2014
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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