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Effects of Silica Dioxide Nanoparticles on the Embryonic Development of Zebrafish
Link to Journal Abstract
To assess the aquatic ecosystem safety of silicon dioxide (SiO2) nanoparticles (NPs), we studied the toxicity of the SiO2 NPs and SiO2 bulk particles (BPs) using zebrafish. Our results show that the SiO2 NPs can significantly affect the development of zebrafish embryos, while there is no obvious effect on survival and development of embryos was found in SiO2 BPs exposure group. The content of malondialdehyde (MDA) in zebrafish larvae exposed to the SiO2 NPs for 108 hours, increased significantly in dose-dependent manner. These results suggest that the SiO2 NPs have toxic effects on the development of zebrafish embryos and the effects could be resulted by oxidative damage.
This study was undertaken to assess the aquatic ecosystem safety of silicon dioxide (SiO2) nanoparticles (NPs) by investigating the toxicity of the SiO2 NPs and SiO2 bulk particles (BPs) using zebrafish.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Environmental Fate and Transport
Risk Exposure Group
Integrated Ferroelectrics, 2013, 147(1): 166-174
Ye R, Yu X, Yang S, Yuan J, Yang X
Last updated on October 2, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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