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Cytotoxicity effects of CdSe quantum dots on testis development of laboratory mice
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Background: There are many promising progresses in biological diagnosis and using quantum dots in nanostructures and multipurpose tools. Nevertheless, in vivo cytotoxicity of these nanoparticles has not been highly considered. For this reason, the cytotoxic effects of CdSe quantum dots on testis development before maturity are presented in this study.
Materials and Methods: In this work, 10, 20 and 40 mg/kg doses of CdSe quantum dots were injected to some one month old male mice. Structural and optical properties of quantum dots were studied by XRD, UV-Vis absorption spectrum and Scanning Tunneling Microscopy and the number of cells in seminiferous tubes of various groups were analyzed using SPSS 16 programme (one way Anova test). Results: Histological studies of testis tissue showed a high toxicity of CdSe in 40 mg/kg dose followed by a decrease in lamina propria, destruction in interstitial tissue, deformation of seminiferous tubes, and reduction in number of spermatogonia, spermatocytes, spermatides, and matured sperms. Although histological study of epididymis tissue showed no significant effect of quantum dots on morphology and structure of tube and its covering epithelium there was a considerable reduction in the lumen content. Conclusion: This study showed a high toxicity of CdSe quantum dots on development of testis tissue, even in lower doses and considering lack of literature review in this field, this study can be an introduction to researches of toxicity effect of quantum dots on development of male reproduction system.
The cytotoxic effects of CdSe quantum dots on testis development in mice before maturity are presented in this study. Various doses of CdSe quantum dots were injected to some one month old male mice and the number of cells in seminiferous tubes of various groups were analyzed using SPSS 16 programme (one way Anova test).
Peer Reviewed Journal Article
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Optoelectronics and Advanced Materials - Rapid Communications, 2013, 7(3-4): 252-257
Optoelectronics and Advanced Materials - Rapid Communications
Valipoor A, Parivar K, Modaresi M, Amiri GR, Messripour M
Last updated on August 20, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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