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Interactions of Engineered Nanoparticles with Organs Protected by Internal Biological Barriers
Link to Journal Abstract
Engineered nanomaterials may exert adverse effects on human health which, in turn, may be linked to their propensity to cross biological barriers in the body. Here, available evidence is discussed, based on in vivo studies for interactions of commercially relevant nanoparticles with critical internal barriers. The internal barriers in focus in this review are the blood–brain barrier, protecting the brain, the blood–testis barrier, protecting the male germ line, and the placenta, protecting the developing fetus. The route of exposure (pulmonary, gastro-intestinal, intravenous, intraperitoneal, dermal), and, hence, the portal of entry of nanoparticles into the body, is of critical importance. Different physico-chemical properties, not only size, may determine the ability of nanoparticles to breach biological barriers; the situation is further compounded by the formation of a so-called corona of biomolecules on the surfaces of nanoparticles, the composition of which may vary depending on the route of exposure and the translocation of nanoparticles from one biological compartment to another. The relevance of nanoparticle interactions with internal biological barriers for their impact on the organs protected by these barriers is also discussed.
In this review, the available evidence, based on in vivo studies for interactions of commercially relevant nanoparticles with critical internal barriers is discussed. The internal barriers in focus in this review are the blood–brain barrier, protecting the brain, the blood–testis barrier, protecting the male germ line, and the placenta, protecting the developing fetus.
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Small, 2013, 9(9-10): 1557-1572
Pietroiusti A, Campagnolo L, Fadeel B
Last updated on June 6, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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