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Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation
Link to Journal Abstract
NanomaterialĖbiosystem interaction is emerging as a major concern hindering wide adoption of nanomaterials. Using quantum dots (Qdots) of different sizes (Qdot-440 nm and Qdot-680 nm) as a model system, we studied the effects of polyethylene glycol (PEG) thin-layer surface modification in attenuating Qdot-related cytotoxicity, genotoxicity perturbation and oxidative stress in a cellular system. We found that uncoated Qdots (U-Qdots) made of core/shell CdSe/ZnS could indeed induce cytotoxic effects, including the inhibition of cell growth. Also, both the neutral comet assay and „H2AX foci formation showed that U-Qdots caused significant DNA damage in a time- and dose-dependent manner. In contrast, results from cytotoxicity analysis and „H2AX generation indicate minimal impact on cells after exposure to PEG-coated Qdots. This lack of observed toxic effects from PEG-coated Qdots may be due to the fact that PEG-coating can inhibit ROS generation induced by U-Qdots. Based on these observations, we conclude that the genotoxicity of Qdots could be significantly decreased following proper surface modification, such as PEG encapsulation. In addition, PEG encapsulation may also serve as a general method to attenuate nanotoxicity for other nanoparticles.
For this study, the authors used quantum dots (Qdots) of different sizes (Qdot-440 nm and Qdot-680 nm) as a model system to investigate the effects of polyethylene glycol (PEG) thin-layer surface modification in attenuating Qdot-related cytotoxicity, genotoxicity perturbation and oxidative stress in a cellular system.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 753(1): 54-64 (April 2013)
Mutation Research/ Genetic Toxicology and Environmental Mutagenesis
Ju L, Zhang C, Zhang C, Sun L, Jiang Y, Yan C, Duerksen-Hughes PJ, Zhang X, Zhu X, Chen FF, Yang J
Last updated on May 9, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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