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Extremely high inhibition activity of photoluminescent carbon nanodots toward cancer cells
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Highly water-soluble, biocompatible, and photoluminescent carbon nanodots (C-dots) having an average diameter 3.4 ± 0.8 nm and a quantum yield 4.3% are obtained from used green tea through grinding, calcination and centrifugation. The as-prepared C-dots are stable in high-ionic-strength media (e.g. 500 mM NaCl) and under light irradiation, allowing images of MCF-10A, MCF-7 and MDA-MB-231 cells to be recorded. The C-dots are mostly localized in the cell membranes and cytoplasms, with evidence of excitation-wavelength cell images. Relative to catechin, the C-dots provide greater inhibition efficiency of the growth of MCF-7 and MDA-MB-231 cancer cells, with lower toxicity for the MCF-10A normal cells. The inhibitory activity of C-dots is associated with the generation of greater amounts of reactive oxygen species. A prothrombin time (PT) assay of plasma samples reveals excellent biocompatibility of the C-dots. To the best of our knowledge, for the first time the C-dots provide inhibition efficiencies up to 80% and 82% for MCF-7 and MDA-MB-231 cancer cells, respectively, showing their high potential as cancer inhibitors.
This study aimed to apply carbon nanodots (C-dots) that had been prepared from used green tea for imaging and inhibition of the growth of cancer cells such as MCF-7, MDA-MB-231, and HeLa cells. The inhibition efficiency of the C-dots on the growth of MCF-7 and MDA-MB-231 cancer cells and toxicity for the MCF-10A normal cells was investigated as part of the study.
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Journal of Materials Chemistry B, 2013, 1(13): 1774-1781
Journal of Materials Chemistry B
Hsu PC, Chen PC, Ou CM, Chang HY, Chang HT
Last updated on April 12, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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