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Structural properties of silver doped hydroxyapatite and their biocompatibility
Link to Journal Abstract
The aim of this study was to obtain a novel hydroxyapatite-based material with high biocompatibility. The structural properties of the samples were well characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray Photoelectron Spectroscopy (XPS). The X-ray diffraction studies revealed the characteristic peaks of hydroxyapatite in each sample. Other phases or impurities were not observed. The scanning electron microscopy observations suggest that the doping components have no influence on the surface morphology of the samples, which reveals a homogeneous aspect of the synthesized particles for all samples. The presence of calcium (Ca), phosphor (P), oxygen (O) and silver (Ag) in the Ag:HAp is confirmed by energy dispersive X-ray (EDAX) and X-ray Photoelectron Spectroscopy analyses. Nanocrystalline silver doped HAp stimulated viability and potentiated the activation of murine macrophages.
This paper describes a simple and low cost methodology to obtain Ag:HAp powders. The study also aimed to understand the effects of Ag:HAp nanoparticles (NPs) with different xAg on macrophage cells.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Material Analysis and Applications
Risk Exposure Group
Materials Science and Engineering: C - Materials for Biological Applications, 33(3): 1395-1402 (April 2013)
Materials Science and Engineering: C
Ciobanu CS, Iconaru SL, Pasuk I, Vasile BS, Lupu AR, Hermenean A, Dinischiotu A, Predoi D
Last updated on April 11, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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