ICON Web & News
Search Using OECD Database
Return to Previous Page
Addition or Correction
Uniform Ultrasmall Graphene Oxide Nanosheets with Low Cytotoxicity and High Cellular Uptake
Link to Journal Abstract
Graphene oxide (GO) is an increasingly important nanomaterial, which exhibits great promise in the area of bionanotechnology and nanobiomedicine. In this study, we synthesized uniform ultrasmall graphene oxide nanosheets with high yield by a convenient way of modified Hummersí method. The uniform ultrasmall GO nanosheets, which exhibit fluorescence property and outstanding stability in a wide range of pH values, were less than 50 nm. Furthermore, because of the advantages of its lateral size, the uniform ultrasmall GO nanosheets showed excellent biocompatibility of lower cytotoxicity and higher cellular uptake amount compared to the random large GO nanosheets. Therefore, the as-prepared uniform ultrasmall GO nanosheets could be explored as the ideal nanocarriers for drug delivery and intracellular fluorescent nanoprobe.
In this study, uniform ultrasmall graphene oxide nanosheets were synthesized with high yield by a convenient way of modified Hummers' method. The study also included investigation of the biocompatibility and cellular uptake of this nanomaterial.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
ACS Applied Materials & Interfaces, 2013, 5(5): 1761-1767
ACS Applied Materials & Interfaces
Zhang H, Peng C, Yang J, Lv M, Liu R, He D, Fan C, Huang Q
Last updated on April 4, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
Why Join Us?
Mission and Strategy
Good Nano Guide
Nano EHS Research Needs
Current Practices Survey