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Title: Exposure to Titanium Dioxide Nanoparticles Induces Autophagy in Primary Human Keratinocytes
Date: 2/2013
  Link to Journal Abstract
Abstract: Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles
Non-technical Summary: In this study, immuno-labeling of LC3 and TEM analysis are used to determine how titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Mammalian
Exposure Pathway Other/Unspecified
Method Of Study In Vitro
Paper Type Hazard
Particle Type Oxide
Production Method Engineered
Risk Exposure Group General Population
Target Audience Technical Research
Citation: Small, 9(3): 387-392 (February 2013)
Publication: Small
Author: Zhao Y, Howe JLC, Yu Z, Leong DT, Chu JJH, Loo JSC, Ng KW
Volume: 9
Number: 3
Pages: 387-392
     


Last updated on March 20, 2013
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
Rice University