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Title:

Toxicity of Silver Nanoparticles at the Air-Liquid Interface

Date:

1/2013

Link to Journal Abstract

Abstract:

Silver nanoparticles are one of the most prevalent nanomaterials in consumer products. Some of these products are likely to be aerosolized, making silver nanoparticles a high priority for inhalation toxicity assessment. To study the inhalation toxicity of silver nanoparticles, we have exposed cultured lung cells to them at the air-liquid interface. Cells were exposed to suspensions of silver or nickel oxide (positive control) nanoparticles at concentrations of 2.6, 6.6, and 13.2 �g cm−2 (volume concentrations of 10, 25, and 50 �g ml−1) and to 0.7 �g cm−2 silver or 2.1 �g cm−2 nickel oxide aerosol at the air-liquid interface. Unlike a number of in vitro studies employing suspensions of silver nanoparticles, which have shown strong toxic effects, both suspensions and aerosolized nanoparticles caused negligible cytotoxicity and only a mild inflammatory response, in agreement with animal exposures. Additionally, we have developed a novel method using a differential mobility analyzer to select aerosolized nanoparticles of a single diameter to assess the size-dependent toxicity of silver nanoparticles.

Non-technical Summary:

For this study, in order to study the inhalation toxicity of silver nanoparticles, the authors have exposed cultured lung cells to silver nanoparticles at the air-liquid interface. Cells were exposed to suspensions of silver or nickel oxide (positive control) nanoparticles at various concentrations and to silver or nickel oxide aerosol at the air-liquid interface.

Content Emphasis

Peer Reviewed Journal Article

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Exposure Pathway

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