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Oxidative stress in juvenile common carp (Cyprinus carpio) exposed to TiO2 nanoparticles
Link to Journal Abstract
Acute toxicity and oxidative stress caused by exposure of titanium dioxide nanoparticles (TiO2-NPs) in juvenile common carp (Cyprinus carpio) were investigated. TiO2-NPs solution was prepared using deionized water and dispersed by sonication. Juvenile carp were exposed to different concentrations (5, 10, 20, 40, and 80 mg/L) of TiO2-NPs. TiO2-NP characteristics (particle morphology, size distribution, and zetapotential) were analyzed using transmission electron microscopy (TEM) and dynamic light scattering (DLS). Different tissue samples (skin, liver, brain, and gill) of fish were dissected, and the biochemical responses (catalase [CAT] and glutathione S-transferase [GST] activities) were measured. The results showed that acute exposure to TiO2-NPs induced GST and CAT levels to vary in all observed organs. The effective concentration of TiO2-NPs was 20 mg/L in the liver and brain and 40 mg/L in the gill. Histopathological changes were as follows: (1) skin: hypertrophy and increased number of mucous cells and thickening of the epidermal layer; (2) gill: hypertrophy of chloride cells, degeneration of mucous cells, and increased acidification of mucous cells; and (3) liver: hyperplasia and cytoplasm vacuolation of hepatic cells. No lethal effects were observed during the acute test. Our results show that there is a potential risk of TiO2-NP exposure to aquatic organisms in the environment.
For this study, acute toxicity and oxidative stress caused by exposure of titanium dioxide nanoparticles (TiO2-NPs) in juvenile common carp (Cyprinus carpio) were investigated. Different tissue samples (skin, liver, brain, and gill) of fish were dissected, and the biochemical responses (catalase [CAT] and glutathione S-transferase [GST] activities) were measured.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Environmental Fate and Transport
Risk Exposure Group
Molecular & Cellular Toxicology, 8(4): 357-366 (December 2012)
Molecular & Cellular Toxicology
Lee BC, Kim KT, Cho JG, Lee JW, Ryu TK, Yoon JH, Lee SH, Duong CN, Eom IC, Kim PJ, Choi KH
Last updated on February 21, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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