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Toxicity of Engineered Nanomaterials: A Physicochemical Perspective
Link to Journal Abstract
The global market for nanomaterial-based products is forecasted to reach 100 billion dollars per annum for 2011–2015. Extensive manufacturing and the use of engineered nanomaterials have raised concerns regarding their impact on biological response in living organisms and the environment at large. The fundamental properties of nanomaterials exhibit a complex dependence upon several factors such as their morphology, size, defects, and chemical stability. Therefore, it is exceedingly difficult to correlate their biological response with their intricate physicochemical properties. For example, varying toxic response may ensue due to different methods of nanomaterial preparation, dissimilar impurities, and defects. In this review, we surveyed the existing literature on the dependence of cytotoxicity on physicochemical properties. We found that ENM size, shape, defect density, physicochemical stability, and surface modification to be the main causes that elicit altered physiological response or cytotoxicity.
In this review, the authors surveyed the existing literature on the dependence of cytotoxicity on physicochemical properties. They summarize the impact of ENM size, shape, defect density, physicochemical stability, and surface modification altered physiological response or cytotoxicity.
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Journal of Biochemical and Molecular Toxicology, 27(1): 50-55 (January 2013)
Journal of Biochemical and Molecular Toxicology
Podila R, Brown JM
Last updated on February 13, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
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