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Title:

Emerging Techniques in Proteomics for Probing Nano�Bio Interactions

Date:

12/2012

Link to Journal Abstract

Abstract:

Nanoengineered particles that can facilitate drug formulation and improve specificity of delivery afford exciting opportunities for improved lesion-specific therapy. Understanding and controlling the nano�bio interactions of these materials is central to future developments in this area. Mass-spectrometry-based proteomics techniques, in conjunction with other emerging technologies, are enabling novel insights into the modulation of particle surfaces by biological fluids (formation of the protein corona) and subsequent particle-induced cellular responses. In this Perspective, we summarize important recent developments using proteomics-based techniques to understand nano�bio interactions and discuss the impact of such knowledge on improving particle design.

Non-technical Summary:

In this Perspective, the authors summarize important recent developments using proteomics-based techniques to understand nano�bio interactions and discuss the impact of such knowledge on improving particle design.

Content Emphasis

Review Article

Exposure Or Hazard Target

Exposure Pathway

Method Of Study

Paper Type

Particle Type