ICON Web & News
Search Using OECD Database
Return to Previous Page
Addition or Correction
Polyvinyl alcohol functionalized cobalt ferrite nanoparticles for biomedical applications
Link to Journal Abstract
In the present work, cobalt ferrite nanoparticles (CoFe2O4 NPs) have been synthesized by combustion method. The surface of the CoFe2O4 NPs was modified with biocompatible polyvinyl alcohol (PVA). To investigate effect and nature of coating on the surface of CoFe2O4 NPs, the NPs were characterized X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA). The transmission electron microscopy (TEM) and dynamic light scattering (DLS) results demonstrate the monodispersed characteristics of CoFe2O4 NPs after surface modification with PVA. The decrease in contact angle from 162° to 50° with PVA coating on NPs indicates the transition from hydrophobic nature to hydrophilic. The Magnetic properties measurement system (MPMS) results show that the NPs have ferromagnetic behavior with high magnetization of 75.04 and 71.02 emu/g of uncoated and coated CoFe2O4 NPs respectively. These PVA coated NPs exhibit less toxicity over uncoated CoFe2O4 NPs up to 1.8 mg mL−1 when tested with mouse fibroblast L929 cell line.
In this work, cobalt ferrite nanoparticles (CoFe2O4 NPs) have been synthesized by combustion method and the surface of the CoFe2O4 NPs was modified with biocompatible polyvinyl alcohol (PVA). The PVA coated NPs evaluated against uncoated CoFe2O4 NPs by testing with mouse fibroblast L929 cell line.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Applied Surface Science, 264: 598-604 (January 2013)
Applied Surface Science
Salunkhe AB, Khot VM, Thorat ND, Phadatare MR, Sathish CI, Dhawale DS, Pawar SH
Last updated on January 25, 2013
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
Why Join Us?
Mission and Strategy
Good Nano Guide
Nano EHS Research Needs
Current Practices Survey