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Title:

Differential response of macrophages to core�shell Fe3O4@Au nanoparticles and nanostars

Date:

11/2012

Link to Journal Abstract

Abstract:

Murine RAW 264.7 cells were exposed to spheroidal core�shell Fe3O4@Au nanoparticles (SCS-NPs, ca. 34 nm) or nanostars (NSTs, ca. 100 nm) in the presence of bovine serum albumin, with variable effects observed after macrophagocytosis. Uptake of SCS-NPs caused macrophages to adopt a rounded, amoeboid form, accompanied by an increase in surface detachment. In contrast, the uptake of multibranched NSTs did not induce gross changes in macrophage shape or adhesion, but correlated instead with cell enlargement and signatures of macrophage activation such as TNF-� and ROS. MTT assays indicate a low cytotoxic response to either SCS-NPs or NSTs despite differences in macrophage behavior. These observations show that differences in NP size and shape are sufficient to produce diverse responses in macrophages following uptake.

Non-technical Summary:

In this study, murine RAW 264.7 cells were exposed to spheroidal core�shell Fe3O4@Au nanoparticles (SCS-NPs, ca. 34 nm) or nanostars (NSTs, ca. 100 nm) in the presence of bovine serum albumin, and the effects of exposure to the nanoparticles were observed after macrophagocytosis.

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Peer Reviewed Journal Article

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