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Title: Multi walled carbon nano tubes induced hepatotoxicity in Swiss albino mice
Date: 1/2013
  Link to Journal Abstract
Abstract: In the present study, multi walled carbon nano tubes (MWCNTs) were synthesized using chemical vapour deposition (CVD) technique. Swiss albino mice were orally administered with single dose of 60 and 100 mg/kg body weight of purified and functionalized MWCNTs suspended in water. The mice were autopsied on 7, 14, 21 and 28 days post exposure. Liver was taken out and part of it fixed in Bouin's solution for histopathological examinations. The remaining part was immersed in cold saline, blotted dry, weighed quickly and homogenized in ice cold buffer. The activity of superoxide dismutase (SOD) and catalase (CAT) was immediately measured in the supernatant. The MWCNTs in liver led to pathological changes, including injury to macrophages, cellular swelling, unspecific inflammation, spot necrosis and blood coagulation. Estimation of SOD and CAT showed altered levels in the experimental groups as compared to controls. Therefore, MWCNTs from manufactured and combustion sources in the environment can have adverse effects on human health.
Non-technical Summary: In this study, multi walled carbon nano tubes (MWCNTs) were synthesized using chemical vapour deposition (CVD) technique and swiss albino mice were orally administered with single dose of 60 and 100 mg/kg body weight of purified and functionalized MWCNTs suspended in water. The mice were autopsied on several days post exposure. Liver was taken out and part of it fixed in Bouin's solution for histopathological examinations.
Content Emphasis Peer Reviewed Journal Article
Exposure Or Hazard Target Mammalian
Exposure Pathway Oral/Ingestion
Method Of Study In Vivo
Paper Type Hazard
Particle Type Carbon
Production Method Engineered
Risk Exposure Group General Population
Target Audience Technical Research
Citation: Micron, 44: 359-364 (January 2013)
Publication: Micron
Author: Awasthi KK, John PJ, Awasthi A, Awasthi K
Volume: 44
Pages: 359-364
     


Last updated on January 3, 2013
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This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.

 		 
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