ICON Web & News
Search Using OECD Database
Return to Previous Page
Addition or Correction
In vivo assessment of CdSe–ZnS quantum dots: coating dependent bioaccumulation and genotoxicity
Link to Journal Abstract
Semiconductor nanocrystals, or Quantum Dots (QDs), have gained considerable attention due to their unique size-dependent optical and electronic properties that make them attractive for a wide range of applications, including biology and nanomedicine. Their widespread use, however, poses urgent questions about their potential toxicity, especially because of their heavy metal composition that could cause harmful effects to human health and environment. In this work, we evaluated in vivo the long-term toxicity of CdSe–ZnS QDs with different surface coatings, probing oral administration in the model system Drosophila melanogaster. In particular, we found that all the differently coated QDs significantly affect the lifespan of treated Drosophila populations and induce a marked increase in reactive oxygen species (ROS) levels. Furthermore, we observed that these QDs induce severe genotoxic effects and increased rate of apoptosis in Drosophila haemocytes. These toxic effects were found to be mainly related to the in vivo degradation of QDs with consequent release of Cd2+ ions, while the coating of QDs can modulate their bioaccumulation in the organism, partly decreasing their overall toxicity.
In this work, the authors evaluated in vivo the long-term toxicity of CdSe–ZnS Quantum Dots (QDs) with different surface coatings, probing oral administration in the model system Drosophila melanogaster.
Peer Reviewed Journal Article
Exposure Or Hazard Target
Method Of Study
Risk Exposure Group
Nanoscale, 2012, 4(20): 6401-6407
Galeone A, Vecchio G, Malvindi MA, Brunetti V, Cingolani R, Pompa PP
Last updated on December 12, 2012
This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation
under NSF Award Number EEC-0118007.
Why Join Us?
Mission and Strategy
Good Nano Guide
Nano EHS Research Needs
Current Practices Survey